Clinical Care
Appointments in clinical immunology, rare diseases and inborn errors of immunity, available in person at the Center for Genomic Medicine in Immunology and by telemedicine.
Physician-immunologist · MD, PhD
João Bosco
Oliveira Filho.
Clinical immunology and genomic medicine
Physician and researcher focused on immune disorders and rare diseases. Trained at the NIH, with experience in genetic diagnosis, scientific research and clinical care.
In-person appointments in Recife and telemedicine consultations.
CRM-PE 12563 · RQE 8733 · CRM-SP 123555
CEO and founder of NeoGenomicaFounder of Genomika DiagnósticosTraining and research at the NIH
Genomic and Precision Medicine
Clinical selection and interpretation of gene panels, exome and genome sequencing, integrating medical history, laboratory data and molecular findings.
Science and Entrepreneurship
Research, innovation, and the creation of companies and projects that expand access to genomics and bring scientific evidence closer to healthcare practice.
He earned his medical degree from the University of Pernambuco (UPE) and completed his Internal Medicine residency at the Federal University of Pernambuco (UFPE). He undertook a postdoctoral fellowship in clinical and laboratory immunology at the National Institutes of Health (NIH, USA) and earned doctorates in Pathology from the University of São Paulo (USP) and in Experimental Immunology from the University of Amsterdam (the Netherlands).
At the NIH, he led the Human Disorders of Lymphocyte Homeostasis Unit and served as Assistant Chief of the Flow Cytometry and Genetics Service. In 2013, he founded Genomika Diagnósticos, which he led until its integration into Hospital Israelita Albert Einstein. At Einstein, he directed molecular genetics, precision medicine and the Brazilian Rare Genomes Project.
Full biography
Founder and coordinator of the Brazilian Rare Genomes Project — a nationwide initiative involving 10,305 participants across 21 centers — he also served as CEO of Genesis Genomics. He is currently CEO and founder of NeoGenomica, CEO and co-founder of Co-Human Genomics, and coordinator of the Immunobiologics Center at Hospital Memorial Star.
His work connects immunology, monogenic disease discovery and genomics at scale. He has authored or co-authored more than 80 scientific papers, including publications in PNAS, Blood, Nature Immunology and Science.
Career
Education and career.
Training in Brazil, the United States and the Netherlands; immunology research and leadership in genomic medicine.
EducationAcademic training
- 19981992–1998
Medical Degree
University of Pernambuco (UPE)
Completion of medical school and the beginning of his clinical career.
- 20021999–2002
Internal Medicine Residency
Federal University of Pernambuco (UFPE)
Specialist training in Internal Medicine.
- 20062003–2006
Clinical Laboratory Immunology Fellowship
National Institutes of Health (NIH), United States
Research in clinical laboratory immunology, immunogenetics and apoptosis.
- Aug 21, 20082006–2008
PhD in Pathology
University of São Paulo (USP)
Doctoral thesis on an NRAS mutation and human autoimmune lymphoproliferative syndrome.
View source - May 12, 20112005–2011
PhD in Experimental Immunology
University of Amsterdam (UvA), the Netherlands
Doctoral thesis on human immunology through the study of primary immunodeficiencies.
View source
LeadershipProfessional career
- 2003–2006Bethesda, USA
Postdoctoral Fellow
National Institutes of Health (NIH)
Fellowship in clinical and laboratory immunology, with full-time research in immunogenetics and apoptosis.
View source - 2008–2012Bethesda, USA
Unit Head and Assistant Service Chief
National Institutes of Health (NIH)
Head of the Human Disorders of Lymphocyte Homeostasis Unit and Assistant Chief of the Flow Cytometry and Genetics Service in the Department of Laboratory Medicine.
View source - 2013–2021Recife, Brazil
CEO and Founder
Genomika Diagnósticos
Founded and led one of Brazil's pioneering high-complexity genetics laboratories.
View source - 2020Strategic integration
Genomika acquisition by Einstein
Hospital Israelita Albert Einstein
Completion of the controlling-interest acquisition and integration of Genomika operations into Sociedade Israelita Brasileira Albert Einstein.
View source - 2021–Apr 2024São Paulo, Brazil
Medical Manager of Genomics
Hospital Israelita Albert Einstein
Led the Molecular Genetics Laboratory, Precision Medicine Program and Brazilian Rare Genomes Project.
View source - Aug 2023–Jun 2024Brazil
CEO
Genesis Genomics
Executive leadership of the genomics joint venture created by Grupo Fleury and Hospital Israelita Albert Einstein.
View source - Oct 2024–presentRecife, Brazil
CEO and Founder
NeoGenomica
Executive and scientific leadership of a laboratory dedicated to precision medicine and advanced genetic sequencing.
View source - Jan 2026–presentRecife, Brazil
Coordinator, Immunobiologics Center
Hospital Memorial Star
Coordinates a center specializing in immunobiologic therapies at Hospital Memorial Star in Recife.
View source - 2025–presentBrazil
CEO and Co-founder
Co-Human Genomics
Created a platform integrating clinical genomics, artificial intelligence and continuous health monitoring.
View source
Science
Selected publications
- PNAS2007
NRAS mutation causes a human autoimmune lymphoproliferative syndrome
Described an activating germline NRAS mutation as a cause of human autoimmune lymphoproliferative syndrome; first author.
Open publication - Blood2010
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
Consensus diagnostic criteria and classification from the NIH international workshop; first author.
Open publication - Blood2011
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
Expanded the spectrum of RAS-associated autoimmune and lymphoproliferative disorders; senior author.
Open publication - Blood2013
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans
Identified PKCδ loss of function as a cause of B-cell lymphoproliferation and autoimmunity; senior author.
Open publication - Nature Immunology2013/14
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
Activating germline PIK3CD mutations associated with T-cell senescence and immunodeficiency.
Open publication - Science2014
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
Demonstrated that CTLA-4 haploinsufficiency causes immune dysregulation in humans.
Open publication - Frontiers in Molecular Biosciences2022
The Brazilian Rare Genomes Project: Validation of Whole Genome Sequencing for Rare Diseases Diagnosis
Validation of whole-genome sequencing for rare disease diagnosis; corresponding author.
Open publication - Human Genetics and Genomics Advances2026
Genome Sequencing for the Diagnosis of Rare Disorders: The Brazilian Rare Genomes Project
National landmark involving 10,305 participants at 21 centers, 9,448 reports and an overall diagnostic yield of 35.6%.
Open publication
Scientific output
Projects, media and publications.
A selection from his academic career, including scientific papers, research projects and interviews on genomics, immunology and precision medicine.
88 scientific papers4 featured projects29 interviews and news items
Projects
2020–present · Ongoing
Brazilian Rare Genomes Project
Whole-genome sequencing of thousands of patients with rare diseases in public healthcare services, aiming to accelerate diagnosis and improve clinical care in Brazil.
View project2008–2012 · Completed
Diagnosis, genetics and pathogenesis of primary immunodeficiencies
NIH projects on the genetics, diagnosis and basic science of autoimmune lymphoproliferative syndrome and other primary immunodeficiencies.
2008–2012 · Completed
Applications of Next-Generation Sequencing for the study of immunodeficiencies
Application of next-generation sequencing to the molecular study of immunodeficiencies.
2009–2011 · Completed
Genetics of Autoinflammatory Syndromes
Multicenter project on the prevalence and genetics of autoinflammatory syndromes in the pediatric population.
Interviews and media
2026 · Blog do Magno
Maior estudo genômico da América Latina reforça impacto da medicina de precisão no SUS
2026 · Banco do NordesteBanco do Nordeste financia pesquisa que pode antecipar diagnósticos e prevenir câncer
2026 · PR NewswireMGI Tech e NeoGenômica ampliam o acesso à genômica de alto rendimento no Brasil
2025 · Fundação do CâncerFundação do Câncer conduz painel sobre avanços tecnológicos no diagnóstico oncológico na FISweek 2025
2025 · Jornal do CommercioA genética como ferramenta de transformação na oncologia
2025 · Jornal do CommercioNeoGenômica implementa o teste genético mais poderoso do mundo com foco em precisão e agilidade nos diagnósticos
View all interviews (29)
2025 · Na Rua Tem
Em São Paulo, o imunologista João Bosco apresenta nova iniciativa em genética e reforça os avanços da área no Brasil
2025 · Blog do MagnoRecife no debate nacional sobre doenças raras
2025 · Hospital Israelita Albert EinsteinDia Internacional da Síndrome de Down terá como tema conectar
2025 · Hospital Israelita Albert EinsteinO que é a fibrose cística?
2024 · SBPC/MLOncogenética: uma inovação de importância vital na patologia clínica
2024 · LabNetworkComo testes genéticos estão revolucionando os tratamentos
2024 · CanaltechComo o Brasil investiga doenças raras presentes no DNA através do SUS
2022 · LabNetworkConferência expõe aplicações da genômica para diagnósticos e medidas preventivas em diversas áreas da medicina
2022 · Saúde BusinessComo a medicina personalizada está sendo impulsionada com tecnologias avançadas
2021 · Correio BrazilienseProjeto já ajudou duas mil crianças
2021 · Folha de S.PauloSubnotificadas, doenças raras de origem genética podem confundir pais de primeira viagem
2021 · Câmara Municipal do RecifeComissão Especial Interpartidária de Acompanhamento ao Coronavírus realiza reunião
2020 · O GloboLei que amplia acesso a tratamento contra doenças raras está parada na Câmara
2020 · Folha de S.PauloEinstein vai mapear genoma de 3.500 pacientes com doenças raras
2020 · Portal do HolandaProjeto sequenciará genoma de 3.500 pessoas com doenças raras
2020 · Medicina S/AAlbert Einstein leva sequenciamento genético a pacientes do SUS
2020 · TecMundoBanco genético vai ajudar o SUS a tratar doenças raras
2020 · LabNetworkExame genético auxilia no diagnóstico precoce do câncer de próstata
2020 · SEGSExame genético auxilia na descoberta de doenças não identificadas
2019 · Jornal do CommercioHospital português ganha laboratório de genética
2019 · Hospital Israelita Albert EinsteinExame de microarray auxilia no diagnóstico de doenças genéticas
2018 · Folha de S.PauloBiópsia líquida e mapa genético adiantam detecção do câncer
2018 · Saúde BusinessEinstein inaugura centro de medicina personalizada
Complete list of scientific papers88 publications
2026 · Pediatric Research
Assessment of diagnostic yield and clinical utility of genome sequencing in critically ill infants
DOI: 10.1038/s41390-026-04861-4
2026 · Human Genetics and Genomics Advances
Genome Sequencing for the Diagnosis of Rare Disorders: The Brazilian Rare Genomes Project
DOI: 10.1016/j.xhgg.2026.100624
2025 · Journal of Human Genetics
ACMG secondary findings in the Brazilian rare genomes project: insights from 5402 genome sequencing
DOI: 10.1038/s10038-025-01349-7
2025 · Blood Global Hematology
First Latin America description of myelodysplastic syndrome caused by a novel homozygous missense variant in the ERCC6L2 gene
DOI: 10.1016/j.bglo.2025.100022
2025 · The Cerebellum
Pendular Nystagmus: a Novel Feature of ANO10-Related Disorders
DOI: 10.1007/s12311-025-01828-9
2024 · Journal of Molecular Diagnostics
Assessing the Risk Stratification of Breast Cancer Polygenic Risk Scores in a Brazilian Cohort
DOI: 10.1016/j.jmoldx.2024.06.002
2024 · American Journal of Medical Genetics Part A
CNOT1 p. Arg535Cys variant in holoprosencephaly with late onset diabetes mellitus
DOI: 10.1002/ajmg.a.63836
2024 · American Journal of Medical Genetics Part A
ELMO2 biallelic pathogenic variants in a patient with gingival hypertrophy and cherubism phenotype: Case report and molecular review
DOI: 10.1002/ajmg.a.63602
2024 · Movement Disorders Clinical Practice
Hereditary Truncal Dystonia Associated with ANO3 Gene Variant
DOI: 10.1002/mdc3.14308
2024 · Clinical Genetics
Split Hand-Foot Malformations-Unveiling Unique Molecular Diagnosis From a Brazilian Cohort
DOI: 10.1111/cge.14666
2023 · International Journal for Equity in Health
Challenges and recommendations to increasing the use of exome sequencing and whole genome sequencing for diagnosing rare diseases in Brazil: an expert perspective
DOI: 10.1186/s12939-022-01809-y
2023 · Parkinsonism & Related Disorders
Fragile X premutation mimicking late onset hereditary spastic paraplegia
DOI: 10.1016/j.parkreldis.2023.105964
2023 · Clinical and Translational Oncology
Real-world genomic profiling of acute myeloid leukemia and the impact of European LeukemiaNet risk stratification 2022 update
DOI: 10.1007/s12094-023-03195-5
2023 · Human Genomics
The hospital Israelita Albert Einstein standards for constitutional sequence variants classification: version 2023
DOI: 10.1186/s40246-023-00549-6
2022 · Journal of Allergy and Clinical Immunology: Global
Efficacy of Dupilumab for the treatment of severe skin disease in Cytotoxic T-Lymphocyte Antigen-4 Insufficiency: a role of type 2 inflammation?
DOI: 10.1016/j.jacig.2022.08.004
2022 · Frontiers in Genetics
Genomic study of nonsyndromic hearing loss in unaffected individuals: Frequency of pathogenic and likely pathogenic variants in a Brazilian cohort of 2,097 genomes
DOI: 10.3389/fgene.2022.921324
2022 · Journal of Clinical Immunology
Inborn Errors of Immunity in Patients with Adverse Events Following BCG Vaccination in Brazil
DOI: 10.1007/s10875-022-01302-9
2022 · Scientific Reports
Neoadjuvant chemotherapy or upfront surgery in localized pancreatic cancer: a contemporary analysis
DOI: 10.1038/s41598-022-17743-6
2022 · Frontiers in Molecular Biosciences
The Brazilian Rare Genomes Project: Validation of Whole Genome Sequencing for Rare Diseases Diagnosis
DOI: 10.3389/fmolb.2022.821582
2022 · European Journal of Human Genetics
The genetics of hereditary cancer risk syndromes in Brazil: a comprehensive analysis of 1682 patients
DOI: 10.1038/s41431-022-01098-7
2022 · Clinical Genetics
Vertebral segmentation defects in a Brazilian cohort: Clinical and molecular analysis focused on spondylocostal dysostosis
DOI: 10.1111/cge.14118
2021 · Frontiers in Immunology
A Critical Review on the Standardization and Quality Assessment of Nonfunctional Laboratory Tests Frequently Used to Identify Inborn Errors of Immunity
DOI: 10.3389/fimmu.2021.721289
2021 · Arquivos Brasileiros de Cardiologia
Diretrizes Brasileiras de Hipertensão Arterial - 2020
DOI: 10.36660/abc.20201238
2021 · Parkinsonism & Related Disorders
Quadrupedal gait and cerebellar hypoplasia, the Uner Tan syndrome, caused by ITPR1 gene mutation
DOI: 10.1016/j.parkreldis.2021.10.008
2020 · Rheumatology International
Novel mutation in the NRLP3 manifesting as an intermediate phenotype of cryopyrinopathies
DOI: 10.1007/s00296-020-04683-5
2019 · Neurological Sciences
Guillain-Barre syndrome-the challenge of unrecognized triggers
DOI: 10.1007/s10072-019-03926-z
2017 · American Heart Journal
Atorvastatin for high-risk statin-naive patients undergoing noncardiac surgery: The Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose (LOAD) randomized trial
DOI: 10.1016/j.ahj.2016.11.001
2017 · Journal of Global Oncology
DNA Repair Defect and RAS Mutation in Two Patients With Schistosoma mansoni -Associated Colorectal Cancer: Carcinogenesis Steps or Mere Coincidence?
DOI: 10.1200/jgo.2016.006254
2016 · Results in Immunology
Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus
DOI: 10.1016/j.rinim.2016.04.001
2015 · The Journal of Clinical Investigation
Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency
DOI: 10.1172/jci80477
2015 · Journal of Clinical Immunology
Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings
DOI: 10.1007/s10875-015-0150-8
2015 · Blood
JMML and RALD (RAS-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities
DOI: 10.1182/blood-2014-11-567917
2015 · Forensic Science International
Mutations of desmoglein-2 in sudden death from arrhythmogenic right ventricular cardiomyopathy and sudden unexplained death
DOI: 10.1016/j.forsciint.2015.07.052
2015 · BMC Cancer
Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma
DOI: 10.1186/s12885-015-1473-9
2014 · Human Immunology
Autoimmune manifestations in SCID due to IL7R mutations: Omenn syndrome and cytopenias
DOI: 10.1016/j.humimm.2014.04.006
2014 · European Journal of Neurology
Cryopyrin associated periodic syndrome with neurological involvement in a 50-year-old patient
DOI: 10.1111/ene.12313
2014 · Journal of Clinical Immunology
ICON: The Early Diagnosis of Congenital Immunodeficiencies
DOI: 10.1007/s10875-014-0003-x
2014 · Science
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
DOI: 10.1126/science.1255904
2014 · Blood
Marginal zone B-cell dysfunction in ALPS
DOI: 10.1182/blood-2014-07-585935
2013 · Proceedings of the National Academy of Sciences of the United States of America
Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK
DOI: 10.1073/pnas.1221211110
2013 · Journal of Clinical Immunology
Compound Heterozygous RAG2 Mutations Mimicking Hyper IgM Syndrome
DOI: 10.1007/s10875-013-9956-4
2013 · Nature Immunology
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110-delta result in T cell senescence and human immunodeficiency
DOI: 10.1038/ni.2771
2013 · Blood
Loss-of-function of the protein kinase C delta causes a B cell lymphoproliferative syndrome in humans
DOI: 10.1182/blood-2012-12-469544
2013 · Current Opinion in Pediatrics
The expanding spectrum of the autoimmune lymphoproliferative syndromes
DOI: 10.1097/mop.0000000000000032
2013 · PLOS ONE
Upregulation of Innate Antiviral Restricting Factor Expression in the Cord Blood and Decidual Tissue of HIV-Infected Mothers
DOI: 10.1371/journal.pone.0084917
2012 · Clinical Immunology
CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome
DOI: 10.1016/j.clim.2012.01.014
2012 · Journal of Clinical Immunology
Erratum to: hereditary autoinflammatory syndromes: a Brazilian Multicenter Study
DOI: 10.1007/s10875-012-9715-y
2012 · Journal of Clinical Immunology
Hereditary Autoinflammatory Syndromes: A Brazilian Multicenter Study
DOI: 10.1007/s10875-012-9688-x
2012 · Current Opinion in Allergy and Clinical Immunology
Monogenic defects in lymphocyte apoptosis
DOI: 10.1097/aci.0b013e3283588da0
2011 · Human Pathology
Distribution of biventricular disease in arrhythmogenic cardiomyopathy: an autopsy study
DOI: 10.1016/j.humpath.2011.06.014
2011 · Journal of Clinical Immunology
Expanding the Clinical and Genetic Spectrum of Human CD40L Deficiency: The Occurrence of Paracoccidioidomycosis and Other Unusual Infections in Brazilian Patients
DOI: 10.1007/s10875-011-9623-6
2011 · The Journal of Immunology
FAS Haploinsufficiency Is a Common Disease Mechanism in the Human Autoimmune Lymphoproliferative Syndrome
DOI: 10.4049/jimmunol.1100021
2011 · Blood
How I treat autoimmune lymphoproliferative syndrome
DOI: 10.1182/blood-2011-07-325217
2011 · Circulation Journal
PKP2 Mutations in Sudden Death From Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) and Sudden Unexpected Death With Negative Autopsy (SUDNA)
DOI: 10.1253/circj.cj-11-0747
2011 · Blood
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
DOI: 10.1182/blood-2010-07-295501
2011 · Blood
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
DOI: 10.1182/blood-2011-07-368084
2010 · Immunity
ALPS - Ten Lessons from an International Workshop on a Genetic Disease of Apoptosis
DOI: 10.1016/j.immuni.2010.03.013
2010 · Blood
Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia
DOI: 10.1182/blood-2010-05-286161
2010 · Journal of Allergy and Clinical Immunology
Laboratory evaluation of primary immunodeficiencies
DOI: 10.1016/j.jaci.2009.08.043
2010 · Current Allergy and Asthma Reports
Molecular- and Flow Cytometry-based Diagnosis of Primary Immunodeficiency Disorders
DOI: 10.1007/s11882-010-0137-8
2010 · Jornal de Pediatria
Pediatric hereditary autoinflammatory syndromes
DOI: 10.2223/jped.2015
2010 · Cardiovascular Pathology
Re: Inherited cardiomyopathies mimicking arrhythmogenic right ventricular cardiomyopathy
DOI: 10.1016/j.carpath.2010.11.002
2010 · Blood
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome: report from the 2009 NIH International Workshop
DOI: 10.1182/blood-2010-04-280347
2010 · Jornal de Pediatria
Sindromes autoinflamatorias hereditarias na faixa etaria pediatrica
DOI: 10.1590/s0021-75572010000500003
2010 · Blood
Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome (ALPS)
DOI: 10.1182/blood-2010-01-263145
2010 · Journal of Allergy and Clinical Immunology
Using biomarkers to predict the presence of FAS mutations in patients with features of the autoimmune lymphoproliferative syndrome
DOI: 10.1016/j.jaci.2009.12.983
2009 · Clinical Chemistry
Functional Flow Cytometry Testing: An Emerging Approach for the Evaluation of Genetic Disease
DOI: 10.1373/clinchem.2008.119248
2009 · Scandinavian Journal of Immunology
Molecular Characterization of Patients with X-linked Hyper-IgM Syndrome: Description of Two Novel CD40L Mutations
DOI: 10.1111/j.1365-3083.2008.02198.x
2008 · Current Opinion in Allergy and Clinical Immunology
Applications of flow cytometry for the study of primary immune deficiencies
DOI: 10.1097/aci.0b013e328312c790
2008 · Journal of Clinical Immunology
Autoimmunity in Hyper-IgM Syndrome
DOI: 10.1007/s10875-008-9171-x
2008 · Biology Direct
Critical role for BIM in T cell receptor restimulation-induced death
DOI: 10.1186/1745-6150-3-34
2008 · Journal of Clinical Immunology
Disorders of Apoptosis: Mechanisms for Autoimmunity in Primary Immunodeficiency Diseases
DOI: 10.1007/s10875-007-9161-4
2008 · Arquivos Brasileiros de Cardiologia
Evolucao clinica muito tardia de pacientes com infarto agudo do miocardio submetidos a angioplastia primaria
DOI: 10.1590/s0066-782x2008000400002
2008 · Arquivos Brasileiros de Cardiologia
Fatores de risco para acidente vascular encefalico apos cirurgia de revascularizacao do miocardio
DOI: 10.1590/s0066-782x2008001600005
2008 · Revista Brasileira de Terapia Intensiva
How to critically assess intensive care cohort studies?
2008 · Journal of Clinical Immunology
Phenotype-Genotype Analysis of Cryopyrin-Associated Periodic Syndromes (CAPS): Description of a Rare Non-Exon 3 and a Novel CIAS1 Missense Mutation
DOI: 10.1007/s10875-007-9150-7
2008 · European Journal of Pediatrics
TNF receptor-associated periodic syndrome (TRAPS): Description of a novel TNFRSF1A mutation and response to etanercept
DOI: 10.1007/s00431-008-0685-2
2008 · Journal of Clinical Immunology
Understanding Systemic Lupus Erythematosus Physiopathology in the Light of Primary Immunodeficiencies
DOI: 10.1007/s10875-008-9187-2
2007 · Clinical Immunology
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome (APECED) Caused by Homozygous P326L AIRE Mutations in a Brazilian Family
DOI: 10.1016/j.clim.2007.03.295
2007 · Revista da Sociedade Brasileira de Clinica Medica
Fatores Determinantes de Sindrome Coronariana Aguda com Arterias Coronarias Normais
2007 · Arquivos Brasileiros de Cardiologia
Fibrilacao atrial no pos-operatorio de cirurgia de revascularizacao do miocardio: caracteristicas do perfil clinico associadas a obitos hospitalares
DOI: 10.1590/s0066-782x2007001300004
2007 · Revista Brasileira de Terapia Intensiva
How to critically assess systematic reviews and meta-analyses?
2007 · Proceedings of the National Academy of Sciences of the United States of America
NRAS mutation causes a human autoimmune lymphoproliferative syndrome
DOI: 10.1073/pnas.0702975104
2007 · Blood
Reversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1)
DOI: 10.1182/blood-2007-04-082552
2007 · Clinical Immunology
Warning Signs for Primary Immunodeficiences Investigation in Hospitalized Patients
DOI: 10.1016/j.clim.2007.03.309
2005 · Current Opinion in Allergy and Clinical Immunology
Autoimmune lymphoproliferative syndrome
2005 · Israel Medical Association Journal
Autoimmune lymphoproliferative syndrome
2004 · Journal of Allergy and Clinical Immunology
Functional and molecular evaluation of lymphocytes
DOI: 10.1016/j.jaci.2004.06.001
Clinical care
Appointments and scheduling.
In-person care in Recife and telemedicine consultations, with access to the Patient Portal for scheduling and follow-up.
Phone / WhatsApp0800 080 0420
Center for Genomic Medicine in Immunology
Clinical appointments at NeoGenomica's headquarters in the Graham Bell business center.
Rua Frei Matias Teves, 285 · Ilha do LeiteRecife/PE · CEP 50070-465Open in Google Maps
Hospital Memorial Star
Clinical office at Hospital Memorial Star, where Dr. João Bosco also coordinates the Immunobiologics Center.
Rua Paissandu, 300 · Boa VistaRecife/PEOpen in Google Maps
In-person and telemedicine appointments
Schedule through the Patient Portal or WhatsApp. The portal also lets you organize documents and follow your care.